Tuesday 1 December 2015

pregnyl 1500 iu by Organon

pregnyl 1500 iu by Organon



Product Description
HCG Pregnyl 1500 IU by Schering-Plough

ONE ORDER UNIT INCLUDES: 1 1500 IU ampoule containing hCG and 1 ml ampoule containing water solution

1 AMPOULE CONTAINS: 1500 IU

TOTAL AMPULES PER ONE ORDER UNIT: 1

TOTAL IU PER ONE ORDER UNIT: 1500 IU

ALTERNATIVE DRUG NAMES: A.P.L., Chorex, Pregnyl, Profasi, Pregnyl IM, hCG, HCG, Human chorionic gonadotropin

ACTIVE SUBSTANCE:

Human chorionic gonadotropin

DESCRIPTION:
hCG (Human chorionic gonadotropin) is used to cause ovulation and to treat infertility in women, and to increase sperm count in men. HCG is also used in young boys when their testicles have not dropped down into the scrotum normally. This can be caused by a pituitary gland disorder.

hCG (Human chorionic gonadotropin) may also be used for other purposes not listed in this medication guide.

HCG (Human chorionic gonadotropin) is given as an injection under the skin or into a muscle. Your doctor, nurse, or other health care provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

DOSAGE AND DIRECTIONS FOR USE:

Dosage in the female:
Ovulation induction or preparation of follicles for puncture
Usually, one injection of 5 000-10 000 I.U. Pregnyl, to complete treatment with an FSH-containing preparation.
Luteal phase support
Two to three repeat injections of 1000 to 3000 I.U. each may be given within nine days following ovulation or embryo transfer (for example on day 3, 6 and 9 after ovulation induction).

Dosage in the male:
Hypogonadotrophic hypogonadism
1000-2000 I.U. Pregnyl, two to three times per week. If the main complaint is subfertility, additional doses of an FSH-containing preparation (75 I.U. FSH) daily or two to three times a week, may be given. This treatment should be continued for at least three months before any improvement in spermatogenesis can be expected. During this treatment testosterone replacement therapy should be suspended. Once achieved, the improvement may sometimes be maintained by hCG alone.
Delayed puberty
1500 I.U. two to three times a week for at least six months.

Cryptorchidism:
- under 2 years of age: 250 I.U. twice weekly for six weeks
- under 6 years of age: 500-1000 I.U. twice weekly for six weeks
- over 6 years of age: 1500 I.U. twice weekly for six weeks
If necessary, this treatment can be repeated.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Reactions at the site of injection, such as bruising, pain, redness, swelling and itching, have been reported with the use of urinary gonadotrophin preparations. Occasionally allergic reactions have been reported, mostly manifesting as pain and/or rash at the injection site. In rare cases generalized rash or fever may occur.
In the female:
Unwanted ovarian hyperstimulation, ovarian hyperstimulation syndrome. Characteristic symptoms of unwanted ovarian hyperstimulation and the ovarian hyperstimulation syndrome are included above, under "Warnings".
In the male:
Water and sodium retention is occasionally seen after administration of high dosages; this is regarded as a result of excessive androgen production.
HCG treatment may sporadically cause gynaecomastia.

Effects on ability to drive and use machines:
As far as known this medicine has no influence on alertness and concentration.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
The acute toxicity of urinary gonadotrophin preparations has been shown to be very low. There are no symptoms of an acute parenteral overdose known in humans.

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