Accent 15mg
Product Description
Product Details:
Accent (Sibutramine) 10mg by Macter Pharma x 1 Pack (14 Capsules)
Composition:
Each Capsule contains Sibutramine hydrochloride monohydrate 10 & 15mg
Sibutramine (usually in the form of the hydrochloride monohydrate salt) is an oral anorexiant. Until 2010 it was marketed and prescribed as an adjunct in the treatment of exogenous obesity along with diet and exercise.
Sibutramine was originally developed and marketed by Knoll Pharmaceuticals and was most recently manufactured and marketed by Abbott Laboratories before its withdrawal from the market. It was sold under a variety of brand names including Reductil, Meridia and Sibutrex.
Prescribing Information: Accent belongs to Sibutramine class which is a weight reducer. Sibutramine is a neurotransmitter reuptake inhibitor that inhibits the reuptake serotonin (by 73%), norepinephrine (by 54%). It helps enhance Satiety. Sibutramine is well absorbed from the GI-Tract (77%), Undergoes a first-pass metabolism reducing its bioavailability. It reaches its peak plasma level after 1 hour. Is metabolized by cytochrome-P450-isoenzyme resulting in 2 active primary and secondary amines (called active metabolites 1 and 2). Peak plasma concentrations of active metabolites 1 and 2 are reached after 3 to 4 hours. Accent is excreted 85% in urine and 15%faeces. Although predominantly inactive metabolites are excreted by the renal route, caution is recommended when treating patients with reduced renal function. Initial dosage is 10mg once daily. In patients with inadequate response to Accent (Sibutramine) at 10mg the dose may be increased to 15mg once daily.
Side effects:
A higher number of cardiovascular events has been observed in people taking sibutramine versus control (11.4% vs. 10.0%). In 2010 the FDA noted the concerns that sibutramine increases the risk of heart attacks and strokes in patients with a history of cardiovascular disease.
Frequently encountered side effects are: dry mouth, paradoxically increased appetite, nausea, strange taste in the mouth, upset stomach, constipation, trouble sleeping, dizziness, drowsiness, menstrual cramps/pain, headache, flushing, or joint/muscle pain.
Sibutramine can substantially increase blood pressure and pulse in some patients. Therefore regular monitoring needs to be performed.
The following side effects are infrequent but serious and require immediate medical attention: cardiac arrhythmias, paresthesia, mental/mood changes (e.g., excitement, restlessness, confusion, depression, rare thoughts of suicide).
Symptoms that require urgent medical attention are seizures, problems urinating, abnormal bruising or bleeding, melena, hematemesis, jaundice, fever and rigors, chest pain, hemiplegia, abnormal vision, dyspnea and edema.
Currently, no case of pulmonary hypertension has been noted, although related compounds (such as Fen-Phen) have shown this rare but clinically significant problem.
Product Details:
Accent (Sibutramine) 10mg by Macter Pharma x 1 Pack (14 Capsules)
Composition:
Each Capsule contains Sibutramine hydrochloride monohydrate 10 & 15mg
Sibutramine (usually in the form of the hydrochloride monohydrate salt) is an oral anorexiant. Until 2010 it was marketed and prescribed as an adjunct in the treatment of exogenous obesity along with diet and exercise.
Sibutramine was originally developed and marketed by Knoll Pharmaceuticals and was most recently manufactured and marketed by Abbott Laboratories before its withdrawal from the market. It was sold under a variety of brand names including Reductil, Meridia and Sibutrex.
Prescribing Information: Accent belongs to Sibutramine class which is a weight reducer. Sibutramine is a neurotransmitter reuptake inhibitor that inhibits the reuptake serotonin (by 73%), norepinephrine (by 54%). It helps enhance Satiety. Sibutramine is well absorbed from the GI-Tract (77%), Undergoes a first-pass metabolism reducing its bioavailability. It reaches its peak plasma level after 1 hour. Is metabolized by cytochrome-P450-isoenzyme resulting in 2 active primary and secondary amines (called active metabolites 1 and 2). Peak plasma concentrations of active metabolites 1 and 2 are reached after 3 to 4 hours. Accent is excreted 85% in urine and 15%faeces. Although predominantly inactive metabolites are excreted by the renal route, caution is recommended when treating patients with reduced renal function. Initial dosage is 10mg once daily. In patients with inadequate response to Accent (Sibutramine) at 10mg the dose may be increased to 15mg once daily.
Side effects:
A higher number of cardiovascular events has been observed in people taking sibutramine versus control (11.4% vs. 10.0%). In 2010 the FDA noted the concerns that sibutramine increases the risk of heart attacks and strokes in patients with a history of cardiovascular disease.
Frequently encountered side effects are: dry mouth, paradoxically increased appetite, nausea, strange taste in the mouth, upset stomach, constipation, trouble sleeping, dizziness, drowsiness, menstrual cramps/pain, headache, flushing, or joint/muscle pain.
Sibutramine can substantially increase blood pressure and pulse in some patients. Therefore regular monitoring needs to be performed.
The following side effects are infrequent but serious and require immediate medical attention: cardiac arrhythmias, paresthesia, mental/mood changes (e.g., excitement, restlessness, confusion, depression, rare thoughts of suicide).
Symptoms that require urgent medical attention are seizures, problems urinating, abnormal bruising or bleeding, melena, hematemesis, jaundice, fever and rigors, chest pain, hemiplegia, abnormal vision, dyspnea and edema.
Currently, no case of pulmonary hypertension has been noted, although related compounds (such as Fen-Phen) have shown this rare but clinically significant problem.
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